Ashtin Chastain made the first basket of the second half, and then a 16-0 Aztecs run ensued.
The deficit grew as large as 42 points with left to play in the game.
Busiest defense in FBS football: Two games has a lot do with it, but San José State's defense has faced more snaps to date than any other Football Bowl Subdivision (FBS) team in games played through September 3. Takeaways matter: The San José State defense recovered three fumbles and turned them into 14 points in the 34-13 win over Cal Poly. USF, the Spartans were intercepted three times that would result in 14 points being scored against them in a 42-22 loss.
Sophomore Sam Allen made his first appearance as a Spartan quarterback for the final series of the Cal Poly win.
San José State's field goal defense ranks fifth in the league at 42.6 percent, while Air Force ranks last for allowing its opponents to shoot 47.7 percent.